Version 5.4
Mus musculus Gene: Angpt1
Summary
InnateDB Gene IDBG-137812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Angpt1
Gene Name angiopoietin 1
Synonyms 1110046O21Rik; Ang-1; Ang1
Species Mus musculus
Ensembl Gene ENSMUSG00000022309
Encoded Proteins
IDBP-137814
angiopoietin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22015631
Angpt1 promotes IL8 synthesis and release in neutrophils. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 22015631
[Homo sapiens] ANGPT1 promotes IL8 synthesis and release in neutrophils.
Entrez Gene
Summary This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blood vessels. This protein also functions in striated muscles by promoting proliferation, migration and differentiation of skeletal myoblasts and plays an essential role in the vascular response to tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:42424727-42676977
Strand Reverse strand
Band B3.1
Transcripts
ENSMUST00000022921 ENSMUSP00000022921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005172 vascular endothelial growth factor receptor binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0001525 angiogenesis
GO:0001569 patterning of blood vessels
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0002040 sprouting angiogenesis
GO:0002092 positive regulation of receptor internalization
GO:0003160 endocardium morphogenesis
GO:0007162 negative regulation of cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007492 endoderm development
GO:0010595 positive regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014842 regulation of satellite cell proliferation
GO:0030097 hemopoiesis
GO:0030210 heparin biosynthetic process
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031398 positive regulation of protein ubiquitination
GO:0031589 cell-substrate adhesion
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034394 protein localization to cell surface
GO:0043066 negative regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0045785 positive regulation of cell adhesion
GO:0048014 Tie signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072012 glomerulus vasculature development
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154188
View Gene Order
ENSBTAG00000014051
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_211860
Tie2 Signaling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
shp2_pathway
SHP2 signaling
Cross-References
SwissProt O08538
TrEMBL Q9CST2
UniProt Splice Variant
Entrez Gene 11600
UniGene Mm.309336
RefSeq NM_001286062 NM_009640 XM_006520323
OMIM
CCDS CCDS27450
HPRD
IMGT
MGI ID MGI:108448
MGI Symbol Angpt1
EMBL AK012027 BC067410 U83509
GenPept AAB50558 AAH67410 BAB27983
RNA Seq Atlas 11600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca