InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ANGPT1

Summary

InnateDB Gene

IDBG-644947.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANGPT1

Gene Name

angiopoietin-1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014051

Encoded Proteins

IDBP-697615

angiopoietin-1 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22015631

[Homo sapiens] ANGPT1 promotes IL8 synthesis and release in neutrophils.

PMID 22015631

[Mus musculus] Angpt1 promotes IL8 synthesis and release in neutrophils. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154188:
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:59137214-59436333

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018675

ENSBTAP00000018675

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0002040	sprouting angiogenesis
GO:0002092	positive regulation of receptor internalization
GO:0007162	negative regulation of cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0010595	positive regulation of endothelial cell migration
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014842	regulation of satellite cell proliferation
GO:0030097	hemopoiesis
GO:0030210	heparin biosynthetic process
GO:0031398	positive regulation of protein ubiquitination
GO:0031589	cell-substrate adhesion
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034394	protein localization to cell surface
GO:0043066	negative regulation of apoptotic process
GO:0043116	negative regulation of vascular permeability
GO:0043524	negative regulation of neuron apoptotic process
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045785	positive regulation of cell adhesion
GO:0048014	Tie signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0072012	glomerulus vasculature development
GO:2000352	negative regulation of endothelial cell apoptotic process