Version 5.4
Mus musculus Gene: Mllt4
Summary
InnateDB Gene IDBG-138450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mllt4
Gene Name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Synonyms 5033403D15Rik; Af-6; AF6; Afadin; Gm314; I-afadin; S-afadin
Species Mus musculus
Ensembl Gene ENSMUSG00000068036
Encoded Proteins
IDBP-536475
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-533726
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-541562
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-535636
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-533654
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-535708
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-534626
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-620769
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130396:
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:13760539-13906150
Strand Forward strand
Band A1
Transcripts
ENSMUST00000139347 ENSMUSP00000115250
ENSMUST00000156591 ENSMUSP00000122204
ENSMUST00000139666 ENSMUSP00000118318
ENSMUST00000137784 ENSMUSP00000119153
ENSMUST00000137708 ENSMUSP00000114485
ENSMUST00000150848 ENSMUSP00000122447
ENSMUST00000137495
ENSMUST00000137503
ENSMUST00000141640
ENSMUST00000136087
ENSMUST00000123030
ENSMUST00000137531 ENSMUSP00000116711
ENSMUST00000124188
ENSMUST00000133422
ENSMUST00000124922
ENSMUST00000170827 ENSMUSP00000128891
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0030054 cell junction
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130396
View Gene Order
ENSBTAG00000005557
Not yet available
Pathways
NETPATH
REACTOME
REACT_248094
Cell-cell junction organization pathway
REACT_230395
Adherens junctions interactions pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
KEGG
mmu04530
Tight junction pathway
mmu04520
Adherens junction pathway
mmu04670
Leukocyte transendothelial migration pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
nectin_pathway
Nectin adhesion pathway
shp2_pathway
SHP2 signaling
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.479700 Mm.59167
RefSeq NM_010806 XM_006523752 XM_006523753 XM_006523754 XM_006523755 XM_006523756 XM_006523757 XM_006523758 XM_006523763 XM_006523764 XM_006523765 XM_006523766
OMIM
CCDS CCDS49955
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca