InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pi4ka

Summary

InnateDB Gene

IDBG-138500.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pi4ka

Gene Name

phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041720

Encoded Proteins

IDBP-138502

phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

IDBP-537146

phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

IDBP-541662

phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

IDBP-539924

phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

IDBP-541175

phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

IDBP-541173

phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000241973:
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:17280351-17406314

Strand

Reverse strand

Band

Transcripts

ENSMUST00000036161	ENSMUSP00000036162
ENSMUST00000127121
ENSMUST00000155928	ENSMUSP00000123156
ENSMUST00000139404
ENSMUST00000154364	ENSMUSP00000122550
ENSMUST00000148110
ENSMUST00000132152
ENSMUST00000142876	ENSMUSP00000121728
ENSMUST00000139768	ENSMUSP00000120752
ENSMUST00000149309	ENSMUSP00000117850
ENSMUST00000132300
ENSMUST00000128938

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004430	1-phosphatidylinositol 4-kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor