InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Enpp3

Summary

InnateDB Gene

IDBG-138907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Enpp3

Gene Name

ectonucleotide pyrophosphatase/phosphodiesterase 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019989

Encoded Proteins

IDBP-138909

ectonucleotide pyrophosphatase/phosphodiesterase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154269:
The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:24773814-24836195

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020169

ENSMUSP00000020169

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004528	phosphodiesterase I activity
GO:0005044	scavenger receptor activity
GO:0016787	hydrolase activity
GO:0030247	polysaccharide binding
GO:0035529	NADH pyrophosphatase activity
GO:0046872	metal ion binding
GO:0047429	nucleoside-triphosphate diphosphatase activity

Biological Process

GO:0006796	phosphate-containing compound metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0008152	metabolic process
GO:0009143	nucleoside triphosphate catabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005576	extracellular region
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000154269

View Gene Order

ENSBTAG00000020196

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00760

Nicotinate and nicotinamide metabolism pathway

mmu00770

Pantothenate and CoA biosynthesis pathway

mmu00500

Starch and sucrose metabolism pathway

mmu00230

Purine metabolism pathway

mmu00740

Riboflavin metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00740

Riboflavin metabolism pathway

hsa00770

Pantothenate and CoA biosynthesis pathway

hsa00760

Nicotinate and nicotinamide metabolism pathway

hsa00230

Purine metabolism pathway

hsa00500

Starch and sucrose metabolism pathway

INOH

INOH website

Nicotinate Nicotinamide metabolism pathway

PID NCI

Cross-References

SwissProt

Q6DYE8

TrEMBL

UniProt Splice Variant

Entrez Gene

209558

UniGene

RefSeq

NM_134005

OMIM

CCDS

CCDS23752

HPRD

IMGT

MGI ID

MGI:2143702

MGI Symbol

Enpp3

EMBL

AC158616 AY630402

GenPept

AAT64421

RNA Seq Atlas

209558