Version 5.4
| Mus musculus Gene: Crkl | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-138913.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Crkl | ||||||||||||||||||||||
| Gene Name | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | ||||||||||||||||||||||
| Synonyms | 1110025F07Rik; AA589403; AI325100; Crkol | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000006134 | ||||||||||||||||||||||
| Encoded Proteins |
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] A type-I-IFN receptor that functions as a nuclear adapter protein and associates with STAT5 to regulate gene transcription through DNA binding
[Homo sapiens] Enterohemorrhagic E. coli NleH1 effector targets CRKL to inhibit ribosomal protein S3 nuclear translocation and the NFκB pathway.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In certain mouse genetic backgrounds this protein is essential for embryonic development. It is important for neural crest cell differentiation and survival and is proposed to play an important role in transducing the oncogenic signal of Bcr/Abl. Deletion of this gene in mouse mimics the phenotype of DiGeorge/velocardiofacial syndrome in human. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 16:17451987-17486255 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | A3 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Cytokine Signaling in Immune system pathway
Immune System pathway
Downstream signal transduction pathway
Frs2-mediated activation pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
Signalling by NGF pathway
Signaling by PDGF pathway
NGF signalling via TRKA from the plasma membrane pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
Prolonged ERK activation events pathway
Regulation of signaling by CBL pathway
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| KEGG |
Renal cell carcinoma pathway
ErbB signaling pathway pathway
Insulin signaling pathway pathway
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Chronic myeloid leukemia pathway
Focal adhesion pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Bacterial invasion of epithelial cells pathway
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| INOH |
GPCR Adenosine A2A receptor signaling pathway pathway
HGF signaling pathway pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL5 pathway
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| REACTOME |
Regulation of signaling by CBL pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Frs2-mediated activation pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signalling by NGF pathway
Cytokine Signaling in Immune system pathway
Signal Transduction pathway
Immune System pathway
Signaling by Interleukins pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Prolonged ERK activation events pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
MAPK signaling pathway pathway
Insulin signaling pathway pathway
Focal adhesion pathway
Chronic myeloid leukemia pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
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| INOH |
GPCR Adenosine A2A receptor signaling pathway pathway
HGF signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Reelin signaling pathway
IGF1 pathway
EPO signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
PDGFR-alpha signaling pathway
IFN-gamma pathway
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.21048 Mm.407247 | ||||||||||||||||||||||
| RefSeq | NM_007764 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS28002 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||