Version 5.4
Mus musculus Gene: Arhgap5
Summary
InnateDB Gene IDBG-139100.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgap5
Gene Name Rho GTPase activating protein 5
Synonyms p190-B; p190B
Species Mus musculus
Ensembl Gene ENSMUSG00000035133
Encoded Proteins
IDBP-259662
Rho GTPase activating protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100852:
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52516077-52567852
Strand Forward strand
Band C1
Transcripts
ENSMUST00000110725 ENSMUSP00000106353
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042169 SH2 domain binding
Biological Process
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008361 regulation of cell size
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100852
View Gene Order
ENSBTAG00000027024
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04670
Leukocyte transendothelial migration pathway
hsa04510
Focal adhesion pathway
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
rac1_pathway
RAC1 signaling pathway
Cross-References
SwissProt
TrEMBL E9PYT0 Q3TQ76
UniProt Splice Variant
Entrez Gene 11855
UniGene Mm.466962 Mm.474991
RefSeq NM_009706 XM_006515438 XM_006515439
OMIM
CCDS CCDS36443
HPRD
IMGT
MGI ID MGI:1332637
MGI Symbol Arhgap5
EMBL AC114002 AC155819 AK163830
GenPept BAE37509
RNA Seq Atlas 11855

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca