InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KEAP1

Summary

InnateDB Gene

IDBG-643288.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KEAP1

Gene Name

kelch-like ECH-associated protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003543

Encoded Proteins

IDBP-695840

kelch-like ECH-associated protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24011591

[Mus musculus] Phosphorylation of Sqstm1 (p62) activates the Keap1-Nrf2 pathway during selective autophagy

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079999:
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:16235815-16244046

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004604

ENSBTAP00000004604

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0010499	proteasomal ubiquitin-independent protein catabolic process
GO:0045604	regulation of epidermal cell differentiation
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005815	microtubule organizing center
GO:0030496	midbody
GO:0031463	Cul3-RING ubiquitin ligase complex