InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gria3

Summary

InnateDB Gene

IDBG-140717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gria3

Gene Name

glutamate receptor, ionotropic, AMPA3 (alpha 3)

Synonyms

2900064I19Rik; GluA3; Glur-3; GluR-C; GluR-K3; Glur3; Gluralpha3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001986

Encoded Proteins

IDBP-140719

glutamate receptor, ionotropic, AMPA3 (alpha 3)

IDBP-250359

glutamate receptor, ionotropic, AMPA3 (alpha 3)

IDBP-535740

glutamate receptor, ionotropic, AMPA3 (alpha 3)

IDBP-533322

glutamate receptor, ionotropic, AMPA3 (alpha 3)

IDBP-624577

glutamate receptor, ionotropic, AMPA3 (alpha 3)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). [provided by RefSeq, Jul 2008]
This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:41400854-41678601

Strand

Forward strand

Band

Transcripts

ENSMUST00000076349	ENSMUSP00000075687
ENSMUST00000115103	ENSMUSP00000110755
ENSMUST00000128197
ENSMUST00000156721
ENSMUST00000139965	ENSMUSP00000116381
ENSMUST00000148212
ENSMUST00000124169	ENSMUSP00000117766
ENSMUST00000126843
ENSMUST00000165288	ENSMUSP00000131523

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic

Cellular Component

GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045211	postsynaptic membrane