InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRIA3

Summary

InnateDB Gene

IDBG-84939.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIA3

Gene Name

glutamate receptor, ionotropic, AMPA 3

Synonyms

GluA3; GLUR-C; GLUR-K3; GLUR3; GLURC; MRX94

Species

Homo sapiens

Ensembl Gene

ENSG00000125675

Encoded Proteins

IDBP-599024

glutamate receptor, ionotrophic, AMPA 3

IDBP-811868

glutamate receptor, ionotropic, AMPA 3

IDBP-811872

glutamate receptor, ionotropic, AMPA 3

IDBP-811881

glutamate receptor, ionotropic, AMPA 3

IDBP-811884

glutamate receptor, ionotropic, AMPA 3

IDBP-811885

glutamate receptor, ionotropic, AMPA 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:123184153-123490915

Strand

Forward strand

Band

q25

Transcripts

ENST00000479118
ENST00000477389
ENST00000460123
ENST00000541091	ENSP00000446440
ENST00000616590	ENSP00000479607
ENST00000611689	ENSP00000478758
ENST00000620443	ENSP00000478489
ENST00000622768	ENSP00000481554
ENST00000620581	ENSP00000481875

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0007215	glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0030666	endocytic vesicle membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045211	postsynaptic membrane