Version 5.4
Mus musculus Gene: Pdss1
Summary
InnateDB Gene IDBG-141408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdss1
Gene Name prenyl (solanesyl) diphosphate synthase, subunit 1
Synonyms 2610203G20Rik; 2700031G06Rik; mDLP1; mSPS1; Tprt; TPT; TPT 1
Species Mus musculus
Ensembl Gene ENSMUSG00000026784
Encoded Proteins
IDBP-141410
prenyl (solanesyl) diphosphate synthase, subunit 1
IDBP-536704
prenyl (solanesyl) diphosphate synthase, subunit 1
IDBP-542291
prenyl (solanesyl) diphosphate synthase, subunit 1
IDBP-542780
prenyl (solanesyl) diphosphate synthase, subunit 1
IDBP-536597
prenyl (solanesyl) diphosphate synthase, subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148459:
The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:22895522-22940266
Strand Forward strand
Band A3
Transcripts
ENSMUST00000053729 ENSMUSP00000055689
ENSMUST00000148072
ENSMUST00000152170 ENSMUSP00000121873
ENSMUST00000135621 ENSMUSP00000116089
ENSMUST00000141215 ENSMUSP00000116206
ENSMUST00000139472
ENSMUST00000149229 ENSMUSP00000114242
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000010 trans-hexaprenyltranstransferase activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0050347 trans-octaprenyltranstransferase activity
Biological Process
GO:0006744 ubiquinone biosynthetic process
GO:0008152 metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0051290 protein heterotetramerization
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148459
View Gene Order
ENSBTAG00000006529
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_196568
Ubiquinol biosynthesis pathway
KEGG
mmu00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160111
Ubiquinol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q33DR2
TrEMBL
UniProt Splice Variant
Entrez Gene 56075
UniGene Mm.249752 Mm.376431
RefSeq NM_019501
OMIM
CCDS CCDS38057
HPRD
IMGT
MGI ID MGI:1889278
MGI Symbol Pdss1
EMBL AB210841 AF118855 BC026820 BC107273 BC107274 CT030013
GenPept AAD24462 AAH26820 AAI07274 AAI07275 BAE48219 CAX15884
RNA Seq Atlas 56075

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca