Version 5.4
Homo sapiens Gene: PDSS1
Summary
InnateDB Gene IDBG-63902.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDSS1
Gene Name prenyl (decaprenyl) diphosphate synthase, subunit 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148459
Encoded Proteins
IDBP-63904
prenyl (decaprenyl) diphosphate synthase, subunit 1
IDBP-589540
prenyl (decaprenyl) diphosphate synthase, subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:26697659-26746798
Strand Forward strand
Band p12.1
Transcripts
ENST00000376215 ENSP00000365388
ENST00000473224
ENST00000491711 ENSP00000435695
ENST00000470978
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000010 trans-hexaprenyltranstransferase activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0050347 trans-octaprenyltranstransferase activity
Biological Process
GO:0006744 ubiquinone biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0044281 small molecule metabolic process
GO:0051290 protein heterotetramerization
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026784
View Gene Order
ENSBTAG00000006529
Not yet available
Pathways
NETPATH
REACTOME
REACT_160111
Ubiquinol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q5T2R2
TrEMBL
UniProt Splice Variant
Entrez Gene 23590
UniGene
RefSeq NM_014317
HUGO HGNC:17759
OMIM 607429
CCDS CCDS31168
HPRD 09591
IMGT
EMBL AB210838 AF118395 AK223414 AL390961 BC049211 BC063635
GenPept AAD28559 AAH49211 AAH63635 BAD97134 BAE48216 CAI17280
RNA Seq Atlas 23590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca