InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptprk

Summary

InnateDB Gene

IDBG-141451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprk

Gene Name

protein tyrosine phosphatase, receptor type, K

Synonyms

AI853699; PTPk; RPTPkappa

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019889

Encoded Proteins

IDBP-628310

protein tyrosine phosphatase, receptor type, K

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152894:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:28074820-28597397

Strand

Forward strand

Band

Transcripts

ENSMUST00000166468

ENSMUSP00000126279

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0045295	gamma-catenin binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0010839	negative regulation of keratinocyte proliferation
GO:0016311	dephosphorylation
GO:0016477	cell migration
GO:0030336	negative regulation of cell migration
GO:0031175	neuron projection development
GO:0034394	protein localization to cell surface
GO:0034614	cellular response to reactive oxygen species
GO:0034644	cellular response to UV
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048041	focal adhesion assembly

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031256	leading edge membrane
GO:0043025	neuronal cell body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000152894

View Gene Order

ENSBTAG00000020829

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Cross-References

SwissProt

P35822

TrEMBL

Q8C819 Q99KV5

UniProt Splice Variant

Entrez Gene

19272

UniGene

Mm.332303 Mm.472426

RefSeq

NM_008983 XM_006512612

OMIM

CCDS

CCDS35874

HPRD

IMGT

MGI ID

MGI:103310

MGI Symbol

Ptprk

EMBL

AK048658 BC003995 L10106

GenPept

AAA40021 AAH03995 BAC33413

RNA Seq Atlas

19272