InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTPRK

Summary

InnateDB Gene

IDBG-632960.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRK

Gene Name

receptor-type tyrosine-protein phosphatase kappa precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020829

Encoded Proteins

IDBP-684630

protein tyrosine phosphatase, receptor type, K

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152894:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:66968686-67594209

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061187

ENSBTAP00000053498

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0045295	gamma-catenin binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0010839	negative regulation of keratinocyte proliferation
GO:0016311	dephosphorylation
GO:0016477	cell migration
GO:0030336	negative regulation of cell migration
GO:0034394	protein localization to cell surface
GO:0034614	cellular response to reactive oxygen species
GO:0034644	cellular response to UV
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048041	focal adhesion assembly

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031256	leading edge membrane
GO:0043025	neuronal cell body

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000152894

View Gene Order

ENSMUSG00000019889

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Cross-References

SwissProt

TrEMBL

F1MME1

UniProt Splice Variant

Entrez Gene

509657

UniGene

Bt.7319

RefSeq

NM_001191537

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02026580 DAAA02026581 DAAA02026582 DAAA02026583 DAAA02026584 DAAA02026585 DAAA02026586 DAAA02026587 DAAA02026588

GenPept

RNA Seq Atlas

509657