Version 5.4
Mus musculus Gene: Exoc2
Summary
InnateDB Gene IDBG-141872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Exoc2
Gene Name exocyst complex component 2
Synonyms 2410030I24Rik; AI648199; Sec5; Sec5l1
Species Mus musculus
Ensembl Gene ENSMUSG00000021357
Encoded Proteins
IDBP-141874
exocyst complex component 2
IDBP-141876
exocyst complex component 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112685:
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:30813919-30974047
Strand Reverse strand
Band A3.2
Transcripts
ENSMUST00000021785 ENSMUSP00000021785
ENSMUST00000102946 ENSMUSP00000100010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017160 Ral GTPase binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006887 exocytosis
GO:0006893 Golgi to plasma membrane transport
GO:0015031 protein transport
GO:0045921 positive regulation of exocytosis
Cellular Component
GO:0000145 exocyst
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112685
View Gene Order
ENSBTAG00000020215
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_207837
Insulin processing pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
insulin_pathway
Insulin Pathway
Cross-References
SwissProt Q9D4H1
TrEMBL
UniProt Splice Variant
Entrez Gene 66482
UniGene Mm.293510
RefSeq NM_025588 XM_006516725 XM_006516726
OMIM
CCDS CCDS26420
HPRD
IMGT
MGI ID MGI:1913732
MGI Symbol Exoc2
EMBL AK016532 AK050068 BC048154 BC049102
GenPept AAH48154 AAH49102 BAB30290 BAC34056
RNA Seq Atlas 66482

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca