InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mgst2

Summary

InnateDB Gene

IDBG-143233.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mgst2

Gene Name

microsomal glutathione S-transferase 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074604

Encoded Proteins

IDBP-143235

microsomal glutathione S-transferase 2

IDBP-541608

microsomal glutathione S-transferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085871:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:51660360-51682675

Strand

Forward strand

Band

Transcripts

ENSMUST00000099106	ENSMUSP00000096705
ENSMUST00000160753
ENSMUST00000161627
ENSMUST00000162195
ENSMUST00000161590	ENSMUSP00000125670
ENSMUST00000159400
ENSMUST00000162125
ENSMUST00000161230
ENSMUST00000159554

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004464	leukotriene-C4 synthase activity
GO:0004602	glutathione peroxidase activity
GO:0008047	enzyme activator activity

Biological Process

GO:0006750	glutathione biosynthetic process
GO:0010243	response to organonitrogen compound
GO:0019370	leukotriene biosynthetic process
GO:0032496	response to lipopolysaccharide
GO:0043085	positive regulation of catalytic activity
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle