InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MGST2

Summary

InnateDB Gene

IDBG-629754.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGST2

Gene Name

Microsomal glutathione S-transferase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021779

Encoded Proteins

IDBP-681168

Microsomal glutathione S-transferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085871:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:18331272-18369333

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000029028

ENSBTAP00000029028

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004464	leukotriene-C4 synthase activity
GO:0004602	glutathione peroxidase activity
GO:0008047	enzyme activator activity
GO:0016740	transferase activity

Biological Process

GO:0006691	leukotriene metabolic process
GO:0006750	glutathione biosynthetic process
GO:0019370	leukotriene biosynthetic process
GO:0043085	positive regulation of catalytic activity
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031090	organelle membrane
GO:0043231	intracellular membrane-bounded organelle