InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Eif2b5

Summary

InnateDB Gene

IDBG-144192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2b5

Gene Name

eukaryotic translation initiation factor 2B, subunit 5 epsilon

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003235

Encoded Proteins

IDBP-144194

eukaryotic translation initiation factor 2B, subunit 5 epsilon

IDBP-542834

eukaryotic translation initiation factor 2B, subunit 5 epsilon

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145191:
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:20498817-20509955

Strand

Forward strand

Band

Transcripts

ENSMUST00000003320	ENSMUSP00000003320
ENSMUST00000148714	ENSMUSP00000121169

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0031369	translation initiation factor binding

Biological Process

GO:0001541	ovarian follicle development
GO:0006413	translational initiation
GO:0006417	regulation of translation
GO:0009408	response to heat
GO:0009749	response to glucose
GO:0014002	astrocyte development
GO:0014003	oligodendrocyte development
GO:0032057	negative regulation of translational initiation in response to stress
GO:0034976	response to endoplasmic reticulum stress
GO:0035690	cellular response to drug
GO:0042552	myelination
GO:0043087	regulation of GTPase activity
GO:0043434	response to peptide hormone
GO:0045948	positive regulation of translational initiation
GO:0048708	astrocyte differentiation