Version 5.4
Bos taurus Gene: EIF2B5
Summary
InnateDB Gene IDBG-635460.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2B5
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011414
Encoded Proteins
IDBP-687337
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145191:
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:83616037-83625122
Strand Reverse strand
Band
Transcripts
ENSBTAT00000015168 ENSBTAP00000015168
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006413 translational initiation
GO:0014002 astrocyte development
GO:0014003 oligodendrocyte development
GO:0034976 response to endoplasmic reticulum stress
GO:0035690 cellular response to drug
GO:0042552 myelination
GO:0048708 astrocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005851 eukaryotic translation initiation factor 2B complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000145191
View Gene Order
ENSMUSG00000003235
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1815
Recycling of eIF2:GDP pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
REACT_254308
Translation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_233572
Gene Expression pathway
REACT_229709
Recycling of eIF2:GDP pathway
KEGG
hsa03013
RNA transport pathway
mmu03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BPB3
UniProt Splice Variant
Entrez Gene 783760
UniGene
RefSeq XM_001251995 XM_002684878
HUGO HGNC:3261
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02001884
GenPept
RNA Seq Atlas 783760

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca