InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dvl3

Summary

InnateDB Gene

IDBG-144321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dvl3

Gene Name

dishevelled 3, dsh homolog (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003233

Encoded Proteins

IDBP-144323

dishevelled 3, dsh homolog (Drosophila)

IDBP-625889

dishevelled 3, dsh homolog (Drosophila)

IDBP-625890

dishevelled 3, dsh homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161202:
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:20516982-20532520

Strand

Forward strand

Band

Transcripts

ENSMUST00000003318	ENSMUSP00000003318
ENSMUST00000171572	ENSMUSP00000130925
ENSMUST00000171774	ENSMUSP00000126082
ENSMUST00000169552

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0003148	outflow tract septum morphogenesis
GO:0007275	multicellular organismal development
GO:0016055	Wnt signaling pathway
GO:0023051	regulation of signaling
GO:0035556	intracellular signal transduction
GO:0035567	non-canonical Wnt signaling pathway
GO:0038031	non-canonical Wnt signaling pathway via JNK cascade
GO:0042493	response to drug
GO:0043507	positive regulation of JUN kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060026	convergent extension
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure