Bos taurus Gene: DVL3
Summary
InnateDB Gene IDBG-635420.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DVL3
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019336
Encoded Proteins
dishevelled, dsh homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161202:
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:83595844-83609419
Strand Reverse strand
Band
Transcripts
ENSBTAT00000025757 ENSBTAP00000025757
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004871 signal transducer activity
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0007275 multicellular organismal development
GO:0016055 Wnt signaling pathway
GO:0035556 intracellular signal transduction
GO:0035567 non-canonical Wnt signaling pathway
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade
GO:0043507 positive regulation of JUN kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
Wnt pathway
REACTOME
PCP/CE pathway pathway
WNT mediated activation of DVL pathway
negative regulation of TCF-dependent signaling by DVL-interacting proteins pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
degradation of DVL pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
Disease pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
degradation of DVL pathway
negative regulation of TCF-dependent signaling by DVL-interacting proteins pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
TCF dependent signaling in response to WNT pathway
Signal Transduction pathway
WNT mediated activation of DVL pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
Wnt signaling pathway pathway
Notch signaling pathway pathway
Basal cell carcinoma pathway
Melanogenesis pathway
Pathways in cancer pathway
Notch signaling pathway pathway
Basal cell carcinoma pathway
Melanogenesis pathway
Wnt signaling pathway pathway
Pathways in cancer pathway
INOH
Wnt signaling pathway pathway
Wnt signaling pathway pathway
PID NCI
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL F1MMW6
UniProt Splice Variant
Entrez Gene 539203
UniGene
RefSeq XM_001788478 XM_002684877
HUGO HGNC:3087
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02001884
GenPept
RNA Seq Atlas 539203