Version 5.4
Mus musculus Gene: Traf3ip2
Summary
InnateDB Gene IDBG-144761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Traf3ip2
Gene Name TRAF3 interacting protein 2
Synonyms Act1; AI429613; CIKS
Species Mus musculus
Ensembl Gene ENSMUSG00000019842
Encoded Proteins
IDBP-144763
TRAF3 interacting protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000056972:
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:39612934-39655307
Strand Forward strand
Band B1
Transcripts
ENSMUST00000019987 ENSMUSP00000019987
ENSMUST00000129693
ENSMUST00000131629
ENSMUST00000156016
ENSMUST00000155945
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001783 B cell apoptotic process
GO:0006959 humoral immune response
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048305 immunoglobulin secretion
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000056972
View Gene Order
ENSBTAG00000008600
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.436686
RefSeq NM_134000
OMIM
CCDS CCDS23789
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca