Bos taurus Gene: TRAF3IP2
Summary
InnateDB Gene IDBG-631425.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAF3IP2
Gene Name adapter protein CIKS
Synonyms C6ORF4
Species Bos taurus
Ensembl Gene ENSBTAG00000008600
Encoded Proteins
adapter protein CIKS
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000056972:
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:39309720-39341546
Strand Forward strand
Band
Transcripts
ENSBTAT00000011347 ENSBTAP00000011347
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001783 B cell apoptotic process
GO:0006959 humoral immune response
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048305 immunoglobulin secretion
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.87724
RefSeq NM_001035483
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas