Version 5.4
Mus musculus Gene: Exosc8
Summary
InnateDB Gene IDBG-144821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Exosc8
Gene Name exosome component 8
Synonyms 2310032N20Rik; CIP3; mKIAA4013
Species Mus musculus
Ensembl Gene ENSMUSG00000027752
Encoded Proteins
IDBP-144823
exosome component 8
IDBP-539479
exosome component 8
IDBP-538088
exosome component 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120699:
This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]
This gene encodes a 3\'-5\' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:54728678-54735393
Strand Reverse strand
Band C
Transcripts
ENSMUST00000029316 ENSMUSP00000029316
ENSMUST00000125632
ENSMUST00000150923
ENSMUST00000134892
ENSMUST00000154787 ENSMUSP00000115876
ENSMUST00000127112
ENSMUST00000153224 ENSMUSP00000118780
ENSMUST00000140935
ENSMUST00000142377
ENSMUST00000135935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017091 AU-rich element binding
Biological Process
GO:0006364 rRNA processing
GO:0008150 biological_process
Cellular Component
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120699
View Gene Order
ENSBTAG00000011855
Not yet available
Pathways
NETPATH
REACTOME
REACT_252013
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_198696
KSRP destabilizes mRNA pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
mmu03018
RNA degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24915
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
REACT_25064
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_25042
KSRP destabilizes mRNA pathway
REACT_20619
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_17015
Metabolism of proteins pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
REACT_212709
KSRP destabilizes mRNA pathway
REACT_207291
PERK regulates gene expression pathway
REACT_226413
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_204438
ATF4 activates genes pathway
REACT_226022
Gene Expression pathway
REACT_213782
Metabolism of proteins pathway
REACT_220156
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_226614
Unfolded Protein Response (UPR) pathway
REACT_203426
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3YYN3
UniProt Splice Variant
Entrez Gene 69639
UniGene Mm.29253
RefSeq NM_001163570 NM_027148
OMIM
CCDS CCDS17352
HPRD
IMGT
MGI ID MGI:1916889
MGI Symbol Exosc8
EMBL AC100927
GenPept
RNA Seq Atlas 69639

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca