Version 5.4
Bos taurus Gene: UGDH
Summary
InnateDB Gene IDBG-641753.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGDH
Gene Name UDP-glucose 6-dehydrogenase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014521
Encoded Proteins
IDBP-694151
UDP-glucose 6-dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109814:
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:60231100-60265819
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019302 ENSBTAP00000019302
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003979 UDP-glucose 6-dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0001702 gastrulation with mouth forming second
GO:0006065 UDP-glucuronate biosynthetic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000109814
View Gene Order
ENSMUSG00000029201
View Gene Order
Pathways
NETPATH
REACTOME
REACT_214113
Formation of the active cofactor, UDP-glucuronate pathway
REACT_218176
Biological oxidations pathway
REACT_219139
Metabolism pathway
REACT_213008
Phase II conjugation pathway
REACT_204452
Glucuronidation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6737
Formation of the active cofactor, UDP-glucuronate pathway
REACT_6784
Glucuronidation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_243247
Phase II conjugation pathway
REACT_188937
Metabolism pathway
REACT_230621
Formation of the active cofactor, UDP-glucuronate pathway
REACT_257519
Glucuronidation pathway
REACT_232343
Biological oxidations pathway
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00500
Starch and sucrose metabolism pathway
hsa00053
Ascorbate and aldarate metabolism pathway
mmu00520
Amino sugar and nucleotide sugar metabolism pathway
mmu00053
Ascorbate and aldarate metabolism pathway
mmu00500
Starch and sucrose metabolism pathway
mmu00040
Pentose and glucuronate interconversions pathway
INOH
PID NCI
Cross-References
SwissProt P12378
TrEMBL
UniProt Splice Variant
Entrez Gene 281564
UniGene Bt.5538
RefSeq NM_174211 XM_005207833
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF095792 BC150068
GenPept AAC64183 AAI50069
RNA Seq Atlas 281564

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca