InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Spg20

Summary

InnateDB Gene

IDBG-145164.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spg20

Gene Name

spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036580

Encoded Proteins

IDBP-145166

spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)

IDBP-265545

spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)

IDBP-401458

spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)

IDBP-401459

spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)

IDBP-534213

spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)

IDBP-540875

spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133104:
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:55112108-55137322

Strand

Forward strand

Band

Transcripts

ENSMUST00000044116	ENSMUSP00000042367
ENSMUST00000107971	ENSMUSP00000103605
ENSMUST00000118118	ENSMUSP00000113621
ENSMUST00000117341	ENSMUSP00000113968
ENSMUST00000149767	ENSMUSP00000119719
ENSMUST00000146109	ENSMUSP00000121683

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0009838	abscission
GO:0030514	negative regulation of BMP signaling pathway
GO:0034389	lipid particle organization
GO:0048698	negative regulation of collateral sprouting in absence of injury
GO:0050905	neuromuscular process
GO:0051301	cell division
GO:0051881	regulation of mitochondrial membrane potential
GO:0060612	adipose tissue development

Cellular Component

GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005811	lipid particle
GO:0005886	plasma membrane
GO:0030496	midbody
GO:0045202	synapse

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000133104

View Gene Order

ENSBTAG00000008040

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.235523

RefSeq

NM_001144987 NM_001144988 NM_144895 XM_006501320

OMIM

CCDS

CCDS38432 CCDS50908

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas