Version 5.4
Bos taurus Gene: SPG20
Summary
InnateDB Gene IDBG-629941.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPG20
Gene Name Spartin
Synonyms spartin
Species Bos taurus
Ensembl Gene ENSBTAG00000008040
Encoded Proteins
IDBP-681369
Spartin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133104:
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:25199123-25229866
Strand Forward strand
Band
Transcripts
ENSBTAT00000010577 ENSBTAP00000010577
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0009838 abscission
GO:0030514 negative regulation of BMP signaling pathway
GO:0034389 lipid particle organization
GO:0048698 negative regulation of collateral sprouting in absence of injury
GO:0050905 neuromuscular process
GO:0051301 cell division
GO:0051881 regulation of mitochondrial membrane potential
GO:0060612 adipose tissue development
Cellular Component
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005811 lipid particle
GO:0005886 plasma membrane
GO:0030496 midbody
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000133104
View Gene Order
ENSMUSG00000036580
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt A0JNJ3
TrEMBL F2Y8L9
UniProt Splice Variant
Entrez Gene 534027
UniGene Bt.21619
RefSeq NM_001077996
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126710 HQ826870
GenPept AAI26711 ADZ53823
RNA Seq Atlas 534027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca