InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pgam2

Summary

InnateDB Gene

IDBG-145227.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pgam2

Gene Name

phosphoglycerate mutase 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020475

Encoded Proteins

IDBP-145229

phosphoglycerate mutase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164708:
Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:5801640-5803733

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020768

ENSMUSP00000020768

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004082	bisphosphoglycerate mutase activity
GO:0004083	bisphosphoglycerate 2-phosphatase activity
GO:0004619	phosphoglycerate mutase activity
GO:0005515	protein binding
GO:0016868	intramolecular transferase activity, phosphotransferases
GO:0046538	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
GO:0048037	cofactor binding

Biological Process

GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006941	striated muscle contraction
GO:0007283	spermatogenesis
GO:0010035	response to inorganic substance
GO:0016311	dephosphorylation
GO:0046689	response to mercury ion