Version 5.4
| Mus musculus Gene: Adcy8 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-145293.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Adcy8 | ||||||||||||||||||||||
| Gene Name | adenylate cyclase 8 | ||||||||||||||||||||||
| Synonyms | AC8; AW060868 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000022376 | ||||||||||||||||||||||
| Encoded Proteins |
adenylate cyclase 8
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] SCN5A is a novel pathogen sensor that initiates anti-viral signalling and transcription through ADCY8 and ATF2.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155897:
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 15:64699042-64922296 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | D1 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
G alpha (s) signalling events pathway
Innate Immune System pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
GPCR downstream signaling pathway
Disease pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Hedgehog 'off' state pathway
Integration of energy metabolism pathway
Ca-dependent events pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Signaling by FGFR in disease pathway
PLC-gamma1 signalling pathway
PKA-mediated phosphorylation of CREB pathway
Adenylate cyclase inhibitory pathway pathway
Metabolism pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
PKA activation in glucagon signalling pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Post NMDA receptor activation events pathway
Activation of GABAB receptors pathway
Aquaporin-mediated transport pathway
Regulation of insulin secretion pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CaM pathway pathway
Inhibition of adenylate cyclase pathway pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Signaling by EGFR pathway
GABA B receptor activation pathway
G alpha (z) signalling events pathway
Phospholipase C-mediated cascade pathway
Transmembrane transport of small molecules pathway
GABA receptor activation pathway
G alpha (i) signalling events pathway
Signalling by NGF pathway
Signaling by PDGF pathway
Neuronal System pathway
DAG and IP3 signaling pathway
Signaling by Hedgehog pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Calmodulin induced events pathway
Adenylate cyclase activating pathway pathway
Signal Transduction pathway
Transmission across Chemical Synapses pathway
Signaling by FGFR pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
PKA activation pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Taste transduction pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Gap junction pathway
GnRH signaling pathway pathway
Long-term potentiation pathway
Purine metabolism pathway
Chemokine signaling pathway pathway
Vascular smooth muscle contraction pathway
Dilated cardiomyopathy pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Salivary secretion pathway
Bile secretion pathway
Pancreatic secretion pathway
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| INOH |
GPCR Adenosine A2A receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
PKA activation pathway
PKA-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
G alpha (i) signalling events pathway
G alpha (s) signalling events pathway
G alpha (z) signalling events pathway
Adenylate cyclase activating pathway pathway
Adenylate cyclase inhibitory pathway pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
GABA B receptor activation pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
Integration of energy metabolism pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
Signaling by FGFR in disease pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Neuronal System pathway
Signaling by GPCR pathway
Innate Immune System pathway
GABA receptor activation pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Hedgehog 'off' state pathway
Post NMDA receptor activation events pathway
G-protein mediated events pathway
Immune System pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inhibition of adenylate cyclase pathway pathway
Ca-dependent events pathway
Aquaporin-mediated transport pathway
Disease pathway
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| KEGG |
GnRH signaling pathway pathway
Gap junction pathway
Purine metabolism pathway
Long-term potentiation pathway
Taste transduction pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Dilated cardiomyopathy pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Salivary secretion pathway
Bile secretion pathway
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| INOH |
GPCR Adenosine A2A receptor signaling pathway pathway
Purine nucleotides nucleosides metabolism pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.1425 | ||||||||||||||||||||||
| RefSeq | NM_009623 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS27506 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||