Version 5.4
| Mus musculus Gene: Tmed7 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-145299.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Tmed7 | ||||||||||
| Gene Name | transmembrane emp24 protein transport domain containing 7 | ||||||||||
| Synonyms | 3930401E15Rik; 5830493P14Rik; AU044611; AW545765; TRAM | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000033184 | ||||||||||
| Encoded Proteins |
transmembrane emp24 protein transport domain containing 7
transmembrane emp24 protein transport domain containing 7
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation | |||||||||||
| Summary |
Tmed7 inhibits LPS-mediated Tlr4 signalling in late endosomes. (Demonstrated in human)
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| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] TMED7;TICAM2 (TICAM2) splice variant TAG negatively regulates the adapter MYD88-independent TLR4 pathway by displacing TICAM1 adapter from TICAM2.
[Homo sapiens] TICAM2 and TICAM1 both function in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to lipopolysaccharide (LPS).
[Homo sapiens] TICAM2 and TICAM1 form an adapter complex that plays a crucial role for LPS-TLR4-mediated activation of IFN-beta.
[Homo sapiens] TMED7;TICAM2 is an adapter protein for both TLR4 and TLR2/6 signaling in synovial fibroblasts, HUVECs, and murine embryonic fibroblasts.
[Homo sapiens] TICAM2 provides specificity for the MYD88-independent component of TLR4 signalling.
[Homo sapiens] TMED7 inhibits LPS-mediated TLR4 signalling in late endosomes.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134970:
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 18:46560235-46597535 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | C | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | D3YZZ5 E9Q7G1 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 66676 | ||||||||||
| UniGene | Mm.296043 Mm.401712 | ||||||||||
| RefSeq | NM_025698 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS50283 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | MGI:1913926 | ||||||||||
| MGI Symbol | Tmed7 | ||||||||||
| EMBL | AC127342 | ||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | 66676 | ||||||||||