Version 5.4
| Bos taurus Gene: TMED7 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-645027.3 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | TMED7 | ||||||||||||
| Gene Name | transmembrane emp24 domain-containing protein 7 precursor | ||||||||||||
| Synonyms | |||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Gene | ENSBTAG00000035030 | ||||||||||||
| Encoded Proteins |
transmembrane emp24 domain-containing protein 7
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||
| Summary |
[Homo sapiens] TMED7;TICAM2 (TICAM2) splice variant TAG negatively regulates the adapter MYD88-independent TLR4 pathway by displacing TICAM1 adapter from TICAM2.
[Homo sapiens] TICAM2 and TICAM1 both function in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to lipopolysaccharide (LPS).
[Homo sapiens] TICAM2 and TICAM1 form an adapter complex that plays a crucial role for LPS-TLR4-mediated activation of IFN-beta.
[Homo sapiens] TMED7;TICAM2 is an adapter protein for both TLR4 and TLR2/6 signaling in synovial fibroblasts, HUVECs, and murine embryonic fibroblasts.
[Homo sapiens] TICAM2 provides specificity for the MYD88-independent component of TLR4 signalling.
[Homo sapiens] TMED7 inhibits LPS-mediated TLR4 signalling in late endosomes.
[Mus musculus] Tmed7 inhibits LPS-mediated Tlr4 signalling in late endosomes. (Demonstrated in human)
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| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134970:
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 10:4409118-4418520 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | |||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | A4IFT6 | ||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 100125926 | ||||||||||||
| UniGene | |||||||||||||
| RefSeq | NM_001105496 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | BC134756 DAAA02027684 | ||||||||||||
| GenPept | AAI34757 | ||||||||||||
| RNA Seq Atlas | 100125926 | ||||||||||||