Version 5.4
Mus musculus Gene: Invs
Summary
InnateDB Gene IDBG-146462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Invs
Gene Name inversin
Synonyms inv; Nphp2
Species Mus musculus
Ensembl Gene ENSMUSG00000028344
Encoded Proteins
IDBP-146464
inversin
IDBP-788846
inversin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119509:
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:48279760-48431954
Strand Forward strand
Band B1
Transcripts
ENSMUST00000030029 ENSMUSP00000030029
ENSMUST00000156602
ENSMUST00000151762
ENSMUST00000149555
ENSMUST00000143433 ENSMUSP00000138580
ENSMUST00000129480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 105 [view]
Protein-Protein 105 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001822 kidney development
GO:0009791 post-embryonic development
GO:0031016 pancreas development
GO:0048513 organ development
GO:0060971 embryonic heart tube left/right pattern formation
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119509
View Gene Order
ENSBTAG00000009806
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.317706 Mm.437104
RefSeq NM_010569 XM_006537626 XM_006537631 XM_006537633
OMIM
CCDS CCDS18166
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca