Version 5.4
Homo sapiens Gene: INVS
Summary
InnateDB Gene IDBG-78659.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INVS
Gene Name inversin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119509
Encoded Proteins
IDBP-78661
inversin
IDBP-78663
inversin
IDBP-78665
inversin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:100099256-100301000
Strand Forward strand
Band q31.1
Transcripts
ENST00000262457 ENSP00000262457
ENST00000262456 ENSP00000262456
ENST00000374921 ENSP00000364056
ENST00000496467
ENST00000480309
ENST00000466647
ENST00000460636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 85 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0001822 kidney development
GO:0009791 post-embryonic development
GO:0016055 Wnt signaling pathway
GO:0031016 pancreas development
GO:0048513 organ development
GO:0060971 embryonic heart tube left/right pattern formation
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005874 microtubule
GO:0005929 cilium
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028344
View Gene Order
ENSBTAG00000009806
Not yet available
Cross-References
SwissProt Q9Y283
TrEMBL A0A024R153
UniProt Splice Variant
Entrez Gene 27130
UniGene Hs.742075
RefSeq NM_014425 NM_183245
HUGO HGNC:17870
OMIM 243305
CCDS CCDS6746 CCDS6747
HPRD
IMGT
EMBL AF039217 AF084367 AF084368 AF084369 AF084370 AF084371 AF084372 AF084373 AF084374 AF084375 AF084376 AF084377 AF084378 AF084379 AF084380 AF084381 AF084382 AL137072 AL356798 AL445214 BC006370 BC041665 BC111761 CH471105
GenPept AAC79436 AAC79456 AAC79457 AAD02131 AAH06370 AAH41665 AAI11762 CAH72173 CAH72174 CAI39744 CAI39745 CAI40807 CAI40808 CAM16212 EAW58924 EAW58925 EAW58926
RNA Seq Atlas 27130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca