Mus musculus Gene: Aff3
Summary
InnateDB Gene IDBG-146921.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aff3
Gene Name AF4/FMR2 family, member 3
Synonyms 3222402O04Rik; A730046J16; LAF-4; Laf4
Species Mus musculus
Ensembl Gene ENSMUSG00000037138
Encoded Proteins
AF4/FMR2 family, member 3
AF4/FMR2 family, member 3
AF4/FMR2 family, member 3
AF4/FMR2 family, member 3
AF4/FMR2 family, member 3
AF4/FMR2 family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144218:
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:38177326-38664955
Strand Reverse strand
Band B
Transcripts
ENSMUST00000095027 ENSMUSP00000092637
ENSMUST00000039827 ENSMUSP00000044128
ENSMUST00000027250 ENSMUSP00000027250
ENSMUST00000142875 ENSMUSP00000118703
ENSMUST00000136641 ENSMUSP00000114638
ENSMUST00000134963 ENSMUSP00000116289
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034612 response to tumor necrosis factor
GO:0035116 embryonic hindlimb morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL D6RHR2
UniProt Splice Variant
Entrez Gene 16764
UniGene Mm.336679 Mm.417907
RefSeq NM_001290814 NM_010678 XM_006495737 XM_006495738 XM_006495740
OMIM
CCDS CCDS69884
HPRD
IMGT
MGI ID MGI:106927
MGI Symbol Aff3
EMBL AC117789 AC122026 AC132381 AC138386
GenPept
RNA Seq Atlas 16764