Version 5.4
Bos taurus Gene: AFF3
Summary
InnateDB Gene IDBG-630378.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFF3
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012449
Encoded Proteins
IDBP-681840
AF4/FMR2 family, member 3
IDBP-681842
AF4/FMR2 family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144218:
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:4632101-4685312
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061254 ENSBTAP00000053656
ENSBTAT00000016523 ENSBTAP00000016523
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
Biological Process
GO:0034612 response to tumor necrosis factor
GO:0035116 embryonic hindlimb morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000144218
View Gene Order
ENSMUSG00000037138
View Gene Order
Cross-References
SwissProt
TrEMBL E1BJW8 F1N772
UniProt Splice Variant
Entrez Gene 787488
UniGene Bt.65831
RefSeq XM_002691147 XM_002700703
HUGO HGNC:6473
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030170
GenPept
RNA Seq Atlas 787488

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca