Version 5.4
Mus musculus Gene: Dph3
Summary
InnateDB Gene IDBG-147256.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dph3
Gene Name DPH3 homolog (KTI11, S. cerevisiae)
Synonyms DELGIP1; DelgipP1; Desr1; KTI11; Zcsl2
Species Mus musculus
Ensembl Gene ENSMUSG00000021905
Encoded Proteins
IDBP-147258
DPH3 homolog (KTI11, S. cerevisiae)
IDBP-147260
DPH3 homolog (KTI11, S. cerevisiae)
IDBP-624777
DPH3 homolog (KTI11, S. cerevisiae)
IDBP-256936
DPH3 homolog (KTI11, S. cerevisiae)
IDBP-538364
DPH3 homolog (KTI11, S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154813:
This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:32080566-32085692
Strand Reverse strand
Band B
Transcripts
ENSMUST00000022461 ENSMUSP00000022461
ENSMUST00000067955 ENSMUSP00000068491
ENSMUST00000112001 ENSMUSP00000127944
ENSMUST00000112000 ENSMUSP00000107631
ENSMUST00000124303 ENSMUSP00000120583
ENSMUST00000144149
ENSMUST00000167796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0050709 negative regulation of protein secretion
GO:0051099 positive regulation of binding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154813
View Gene Order
ENSBTAG00000003916
Not yet available
Cross-References
SwissProt
TrEMBL E9PZC5
UniProt Splice Variant
Entrez Gene 105638
UniGene Mm.2519
RefSeq NM_001047433 NM_001284346 NM_172254
OMIM
CCDS CCDS36860 CCDS36861
HPRD
IMGT
MGI ID MGI:1922658
MGI Symbol Dph3
EMBL AC154846
GenPept
RNA Seq Atlas 105638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca