InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnj1

Summary

InnateDB Gene

IDBG-147450.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnj1

Gene Name

potassium inwardly-rectifying channel, subfamily J, member 1

Synonyms

Kir1.1; ROMK; Romk2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041248

Encoded Proteins

IDBP-147454

potassium inwardly-rectifying channel, subfamily J, member 1

IDBP-623182

potassium inwardly-rectifying channel, subfamily J, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151704:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:32372418-32399192

Strand

Forward strand

Band

Transcripts

ENSMUST00000047334	ENSMUSP00000046793
ENSMUST00000172015	ENSMUSP00000131625

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005524	ATP binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

Biological Process

GO:0001822	kidney development
GO:0001894	tissue homeostasis
GO:0006813	potassium ion transport
GO:0009791	post-embryonic development
GO:0070294	renal sodium ion absorption
GO:0071805	potassium ion transmembrane transport
GO:0072358	cardiovascular system development
GO:1900128	regulation of G-protein activated inward rectifier potassium channel activity

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000151704

View Gene Order

ENSBTAG00000000008

Not yet available

Pathways

NETPATH

REACTOME

REACT_214393

Inwardly rectifying K+ channels pathway

REACT_202800

Potassium Channels pathway

REACT_199080

Potassium transport channels pathway

REACT_259290

Neuronal System pathway

KEGG

mmu04960

Aldosterone-regulated sodium reabsorption pathway

mmu04971

Gastric acid secretion pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_13685

Neuronal System pathway

REACT_75918

Inwardly rectifying K+ channels pathway

REACT_75908

Potassium Channels pathway

REACT_75815

Potassium transport channels pathway

KEGG

hsa04960

Aldosterone-regulated sodium reabsorption pathway

hsa04971

Gastric acid secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.390168

RefSeq

NM_001168354 NM_019659

OMIM

CCDS

CCDS22953 CCDS52751

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas