InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KCNJ1

Summary

InnateDB Gene

IDBG-642800.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ1

Gene Name

ATP-sensitive inward rectifier potassium channel 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000008

Encoded Proteins

IDBP-695294

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151704:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:32757309-32787597

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000008

ENSBTAP00000000008

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

Biological Process

GO:0001822	kidney development
GO:0001894	tissue homeostasis
GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0009791	post-embryonic development
GO:0034765	regulation of ion transmembrane transport
GO:0070294	renal sodium ion absorption
GO:0071805	potassium ion transmembrane transport
GO:0072358	cardiovascular system development
GO:1900128	regulation of G-protein activated inward rectifier potassium channel activity