Version 5.4
Homo sapiens Gene: KCNJ1
Summary
InnateDB Gene IDBG-75955.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNJ1
Gene Name potassium inwardly-rectifying channel, subfamily J, member 1
Synonyms KIR1.1; ROMK; ROMK1
Species Homo sapiens
Ensembl Gene ENSG00000151704
Encoded Proteins
IDBP-75957
potassium inwardly-rectifying channel, subfamily J, member 1
IDBP-75959
potassium inwardly-rectifying channel, subfamily J, member 1
IDBP-245195
potassium inwardly-rectifying channel, subfamily J, member 1
IDBP-245197
potassium inwardly-rectifying channel, subfamily J, member 1
IDBP-245199
potassium inwardly-rectifying channel, subfamily J, member 1
IDBP-384600
potassium inwardly-rectifying channel, subfamily J, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:128836315-128867373
Strand Reverse strand
Band q24.3
Transcripts
ENST00000324036 ENSP00000316233
ENST00000324003 ENSP00000316136
ENST00000392666 ENSP00000376434
ENST00000392665 ENSP00000376433
ENST00000392664 ENSP00000376432
ENST00000440599 ENSP00000406320
ENST00000531562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005242 inward rectifier potassium channel activity
GO:0005524 ATP binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process
GO:0001822 kidney development
GO:0001894 tissue homeostasis
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007588 excretion
GO:0009791 post-embryonic development
GO:0070294 renal sodium ion absorption
GO:0071805 potassium ion transmembrane transport
GO:0072358 cardiovascular system development
GO:1900128 regulation of G-protein activated inward rectifier potassium channel activity
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041248
View Gene Order
ENSBTAG00000000008
Not yet available
Pathways
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_75918
Inwardly rectifying K+ channels pathway
REACT_75908
Potassium Channels pathway
REACT_75815
Potassium transport channels pathway
KEGG
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.527830
RefSeq NM_000220 NM_153764 NM_153765 NM_153766 NM_153767
HUGO
OMIM
CCDS CCDS8476 CCDS8477
HPRD 08981
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca