InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGEF6

Summary

InnateDB Gene

IDBG-87668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF6

Gene Name

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Synonyms

alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA

Species

Homo sapiens

Ensembl Gene

ENSG00000129675

Encoded Proteins

IDBP-87672

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

IDBP-87674

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

IDBP-87676

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:136665547-136782088

Strand

Reverse strand

Band

q26.3

Transcripts

ENST00000370622	ENSP00000359656
ENST00000370620	ENSP00000359654
ENST00000250617	ENSP00000250617

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007254	JNK cascade
GO:0007264	small GTPase mediated signal transduction
GO:0030032	lamellipodium assembly
GO:0032321	positive regulation of Rho GTPase activity
GO:0034329	cell junction assembly
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway