InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dhx36

Summary

InnateDB Gene

IDBG-147779.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhx36

Gene Name

DEAH (Asp-Glu-Ala-His) box polypeptide 36

Synonyms

2810407E23Rik; AI452301; AU022184; Ddx36; mKIAA1488

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027770

Encoded Proteins

IDBP-147781

DEAH (Asp-Glu-Ala-His) box polypeptide 36

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21703541

Dhx36 is a component of a cytosolic viral sensor and is recruited to a complex consisting of Ddx1, Ddx21 and Ticam1, which triggers type I interferon and cytokine response to dsRNA.

InnateDB Annotation from Orthologs

Summary

PMID 20696886

[Homo sapiens] DHX36 interacts with CpG-A and is associated with IFN-alpha production and IRF7 nuclear translocation upon CpG-A stimulation. DHX36 localizes within the cytosol and directly binds to the TLR domain of MYD88.

PMID 21703541

[Homo sapiens] DHX36 is a component of a cytosolic viral sensor and is recruited to a complex consisting of DDX1, DDX21 and TICAM1, which triggers type I interferon and cytokine response to dsRNA. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174953:
This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:62470039-62507004

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029336	ENSMUSP00000029336
ENSMUST00000160858
ENSMUST00000162070

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0002151	G-quadruplex RNA binding
GO:0003676	nucleic acid binding
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008094	DNA-dependent ATPase activity
GO:0042826	histone deacetylase binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0051880	G-quadruplex DNA binding

Biological Process

GO:0001503	ossification
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0009615	response to virus
GO:0010501	RNA secondary structure unwinding
GO:0032206	positive regulation of telomere maintenance
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter