Version 5.4
Mus musculus Gene: Mylip
Summary
InnateDB Gene IDBG-148022.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mylip
Gene Name myosin regulatory light chain interacting protein
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038175
Encoded Proteins
IDBP-148024
myosin regulatory light chain interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000007944:
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:45389742-45412019
Strand Forward strand
Band A5
Transcripts
ENSMUST00000038275 ENSMUSP00000047403
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0006928 cellular component movement
GO:0007399 nervous system development
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0016567 protein ubiquitination
GO:0031648 protein destabilization
GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process
GO:0042632 cholesterol homeostasis
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0055098 response to low-density lipoprotein particle stimulus
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0019898 extrinsic component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000007944
View Gene Order
ENSBTAG00000004115
Not yet available
Cross-References
SwissProt Q8BM54
TrEMBL
UniProt Splice Variant
Entrez Gene 218203
UniGene Mm.212855 Mm.489954
RefSeq NM_153789
OMIM
CCDS CCDS36648
HPRD
IMGT
MGI ID MGI:2388271
MGI Symbol Mylip
EMBL AK034887 AK040836 AK159478 AY434449 BC010206
GenPept AAH10206 AAQ98867 BAC28868 BAC30716 BAE35115
RNA Seq Atlas 218203

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca