Version 5.4
Mus musculus Gene: Eif2b4
Summary
InnateDB Gene IDBG-148070.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif2b4
Gene Name eukaryotic translation initiation factor 2B, subunit 4 delta
Synonyms Eif2b
Species Mus musculus
Ensembl Gene ENSMUSG00000029145
Encoded Proteins
IDBP-148072
eukaryotic translation initiation factor 2B, subunit 4 delta
IDBP-251412
eukaryotic translation initiation factor 2B, subunit 4 delta
IDBP-251414
eukaryotic translation initiation factor 2B, subunit 4 delta
IDBP-531943
eukaryotic translation initiation factor 2B, subunit 4 delta
IDBP-625970
eukaryotic translation initiation factor 2B, subunit 4 delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115211:
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:31187558-31193430
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000077693 ENSMUSP00000076875
ENSMUST00000114605 ENSMUSP00000110252
ENSMUST00000114603 ENSMUSP00000110250
ENSMUST00000153986
ENSMUST00000128037 ENSMUSP00000122583
ENSMUST00000130667
ENSMUST00000139216
ENSMUST00000134888
ENSMUST00000166769 ENSMUSP00000130880
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0014003 oligodendrocyte development
GO:0042552 myelination
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0044237 cellular metabolic process
GO:0045947 negative regulation of translational initiation
GO:0051716 cellular response to stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005851 eukaryotic translation initiation factor 2B complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115211
View Gene Order
ENSBTAG00000019510
Not yet available
Pathways
NETPATH
REACTOME
REACT_254308
Translation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_233572
Gene Expression pathway
REACT_229709
Recycling of eIF2:GDP pathway
KEGG
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1815
Recycling of eIF2:GDP pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.29394
RefSeq NM_001127355 NM_001127356 NM_010122
OMIM
CCDS CCDS19176 CCDS51457
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca