Homo sapiens Gene: EIF2B4
Summary
InnateDB Gene IDBG-38714.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2B4
Gene Name eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Synonyms EIF-2B; EIF2B; EIF2Bdelta;
Species Homo sapiens
Ensembl Gene ENSG00000115211
Encoded Proteins
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Protein Structure
Entrez Gene
Summary Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27364352-27370486
Strand Reverse strand
Band p23.3
Transcripts
ENST00000347454 ENSP00000233552
ENST00000405940 ENSP00000384375
ENST00000445933 ENSP00000394397
ENST00000451130 ENSP00000394869
ENST00000417567 ENSP00000406631
ENST00000418146 ENSP00000407956
ENST00000478311
ENST00000493344 ENSP00000429323
ENST00000475582
ENST00000462749
ENST00000616081 ENSP00000477710
ENST00000622434 ENSP00000479991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0010467 gene expression
GO:0014003 oligodendrocyte development
GO:0032057 negative regulation of translational initiation in response to stress
GO:0042552 myelination
GO:0043434 response to peptide hormone
GO:0043547 positive regulation of GTPase activity
GO:0044237 cellular metabolic process
GO:0044267 cellular protein metabolic process
GO:0045947 negative regulation of translational initiation
GO:0051716 cellular response to stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Translation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Recycling of eIF2:GDP pathway
Gene Expression pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UI10
TrEMBL E7ERK9 F8W8L6
UniProt Splice Variant
Entrez Gene 8890
UniGene Hs.630209
RefSeq NM_001034116 NM_015636 NM_172195 XM_005264632 XM_006712132
HUGO HGNC:3260
OMIM 606687
CCDS CCDS33164 CCDS46244 CCDS46245
HPRD 09459
IMGT
EMBL AC074117 AF112207 AJ011305 AJ011306 AJ011307 AJ011308 BC001870 BC091502 CH471053 JQ991007
GenPept AAF17195 AAH01870 AAH91502 AAY14843 AFM43698 CAB57260 CAB57261 CAB57304 CAB57305 EAX00591
ImmGen EIF2B4 (murine)
RNA Seq Atlas 8890