Homo sapiens Gene: EIF2B4

Summary
InnateDB Gene IDBG-38714.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol EIF2B4
Gene Name eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Synonyms EIF-2B; EIF2B; EIF2Bdelta
Species Homo sapiens
Ensembl Gene ENSG00000115211
Encoded Proteins
IDBP-38716 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
IDBP-294463 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
IDBP-369347 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
IDBP-369354 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
IDBP-369359 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
IDBP-369370 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
IDBP-483599 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Entrez Gene
Summary Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2: 27587219-27593353
Strand Reverse strand
Band p23.3
Transcripts
ENST00000347454  ENSP00000233552
ENST00000405940  ENSP00000384375
ENST00000445933  ENSP00000394397
ENST00000451130  ENSP00000394869
ENST00000417567  ENSP00000406631
ENST00000418146  ENSP00000407956
ENST00000478311 
ENST00000493344  ENSP00000429323
ENST00000475582 
ENST00000462749 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein‑Protein  10
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0009408 response to heat
GO:0009749 response to glucose stimulus
GO:0010467 gene expression
GO:0014003 oligodendrocyte development
GO:0032057 negative regulation of translational initiation in response to stress
GO:0042552 myelination
GO:0043434 response to peptide hormone stimulus
GO:0044237 cellular metabolic process
GO:0044267 cellular protein metabolic process
GO:0045947 negative regulation of translational initiation
GO:0051716 cellular response to stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000029145 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000019510 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_1815 Recycling of eIF2:GDP
KEGG
hsa03013  RNA transport
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UI10 
TrEMBL E7ERK9 F8W8L6
UniProt Splice Variant
Entrez Gene 8890 
UniGene Hs.630209
RefSeq NM_001034116  NM_015636  NM_172195 
HUGO 3260 
OMIM 606687
CCDS CCDS33164  CCDS46244  CCDS46245 
HPRD 09459
IMGT
EMBL AC074117 AF112207 AJ011305 AJ011306 AJ011307 AJ011308 BC001870 BC091502 CH471053 JQ991007
GenPept AAF17195  AAH01870  AAH91502  AAY14843  AFM43698  CAB57260  CAB57261  CAB57304  CAB57305  EAX00591 
ImmGen EIF2B4 (murine) 
RNA Seq Atlas 8890