InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.48888

Summary

InnateDB Gene

IDBG-636666.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.48888

Gene Name

translation initiation factor eIF-2B subunit delta

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019510

Encoded Proteins

IDBP-688613

translation initiation factor eIF-2B subunit delta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115211:
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:72283254-72287762

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025991

ENSBTAP00000025991

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0001541	ovarian follicle development
GO:0006413	translational initiation
GO:0014003	oligodendrocyte development
GO:0042552	myelination
GO:0043547	positive regulation of GTPase activity
GO:0044237	cellular metabolic process
GO:0051716	cellular response to stimulus