Version 5.4
Homo sapiens Gene: SLC9A3R2
Summary
InnateDB Gene IDBG-9763.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC9A3R2
Gene Name solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
Synonyms E3KARP; NHE3RF2; NHERF-2; NHERF2; OCTS2; SIP-1; SIP1; TKA-1
Species Homo sapiens
Ensembl Gene ENSG00000065054
Encoded Proteins
IDBP-364264
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
IDBP-364265
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
IDBP-745579
IDBP-746008
IDBP-753400
IDBP-750927
IDBP-754139
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2025356-2039026
Strand Forward strand
Band p13.3
Transcripts
ENST00000424542 ENSP00000408005
ENST00000432365 ENSP00000402857
ENST00000563587 ENSP00000455909
ENST00000561844 ENSP00000457755
ENST00000565086
ENST00000567504 ENSP00000454361
ENST00000564033
ENST00000566198 ENSP00000456895
ENST00000565855 ENSP00000454690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 71 [view]
Protein-Protein 71 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0019902 phosphatase binding
Biological Process
GO:0006461 protein complex assembly
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002504
View Gene Order
ENSBTAG00000013479
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
lysophospholipid_pathway
LPA receptor mediated events
Cross-References
SwissProt
TrEMBL H3BQS0
UniProt Splice Variant
Entrez Gene 9351
UniGene Hs.440896
RefSeq NM_001130012 NM_001252073 NM_001252075 NM_001252076 NM_004785
HUGO HGNC:11076
OMIM 606553
CCDS CCDS45382 CCDS45383 CCDS58407
HPRD 05946
IMGT
EMBL AC093513
GenPept
RNA Seq Atlas 9351

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca