Version 5.4
Mus musculus Gene: Igfals
Summary
InnateDB Gene IDBG-149536.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Igfals
Gene Name insulin-like growth factor binding protein, acid labile subunit
Synonyms Albs; ALS; mKIAA4111
Species Mus musculus
Ensembl Gene ENSMUSG00000046070
Encoded Proteins
IDBP-149538
insulin-like growth factor binding protein, acid labile subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099769:
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:24878770-24882008
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000050714 ENSMUSP00000060169
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000099769
View Gene Order
ENSBTAG00000033299
Not yet available
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_235886
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P70389
TrEMBL Q570Z9
UniProt Splice Variant
Entrez Gene 16005
UniGene Mm.3135
RefSeq NM_008340 XM_006523711
OMIM
CCDS CCDS37497
HPRD
IMGT
MGI ID MGI:107973
MGI Symbol Igfals
EMBL AK004926 AK220290 U66900
GenPept AAB17270 BAB23677 BAD90215
RNA Seq Atlas 16005

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca