Version 5.4
Mus musculus Gene: St6gal1
Summary
InnateDB Gene IDBG-149606.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol St6gal1
Gene Name beta galactoside alpha 2,6 sialyltransferase 1
Synonyms AW742324; Siat1; St6gal; St6Gal-I; St6galI
Species Mus musculus
Ensembl Gene ENSMUSG00000022885
Encoded Proteins
IDBP-149608
beta galactoside alpha 2,6 sialyltransferase 1
IDBP-249858
beta galactoside alpha 2,6 sialyltransferase 1
IDBP-537125
beta galactoside alpha 2,6 sialyltransferase 1
IDBP-707580
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:23224740-23360350
Strand Forward strand
Band B1
Transcripts
ENSMUST00000023601 ENSMUSP00000023601
ENSMUST00000115335 ENSMUSP00000110992
ENSMUST00000152449
ENSMUST00000128050 ENSMUSP00000121865
ENSMUST00000144919
ENSMUST00000178797 ENSMUSP00000136206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0006054 N-acetylneuraminate metabolic process
GO:0006486 protein glycosylation
GO:0018279 protein N-linked glycosylation via asparagine
GO:0097503 sialylation
Cellular Component
GO:0005576 extracellular region
GO:0030173 integral component of Golgi membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000073849
View Gene Order
ENSBTAG00000010357
Not yet available
Pathways
NETPATH
REACTOME
REACT_198565
N-Glycan antennae elongation pathway
REACT_198566
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_206143
Transport to the Golgi and subsequent modification pathway
REACT_248642
Synthesis of substrates in N-glycan biosythesis pathway
REACT_198517
O-linked glycosylation of mucins pathway
REACT_198575
Termination of O-glycan biosynthesis pathway
REACT_262413
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_202500
Sialic acid metabolism pathway
REACT_204003
O-linked glycosylation pathway
KEGG
mmu00510
N-Glycan biosynthesis pathway
mmu00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25085
N-Glycan antennae elongation pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_115835
Termination of O-glycan biosynthesis pathway
REACT_115606
O-linked glycosylation of mucins pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_25208
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_200727
O-linked glycosylation pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
hsa00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q64685
TrEMBL D3Z1Z5 Q8BM62 Q9JJM6
UniProt Splice Variant
Entrez Gene 20440
UniGene Mm.149029 Mm.414589
RefSeq NM_001252506 NM_001252505 NM_145933 XM_006521873 XM_006521874 XM_006521875 XM_006521876
OMIM
CCDS CCDS28077
HPRD
IMGT
MGI ID MGI:108470
MGI Symbol St6gal1
EMBL AB027197 AC125396 AC154312 AK034768 AK084124 BC027833 BC092222 BC096026 CH466521 D16106
GenPept AAH27833 AAH92222 AAH96026 BAA03680 BAB00636 BAC28828 BAC39120 EDK97666 EDK97667
RNA Seq Atlas 20440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca