InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GIPR

Summary

InnateDB Gene

IDBG-57863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GIPR

Gene Name

gastric inhibitory polypeptide receptor

Synonyms

PGQTL2

Species

Homo sapiens

Ensembl Gene

ENSG00000010310

Encoded Proteins

IDBP-11352

gastric inhibitory polypeptide receptor

IDBP-57865

gastric inhibitory polypeptide receptor

IDBP-761998

IDBP-760129

IDBP-760392

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:45668244-45683724

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000304207	ENSP00000305321
ENST00000263281	ENSP00000263281
ENST00000585889	ENSP00000467342
ENST00000590918	ENSP00000467494
ENST00000591224
ENST00000591322	ENSP00000465385
ENST00000588816
ENST00000593127

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0016519	gastric inhibitory peptide receptor activity
GO:0017046	peptide hormone binding

Biological Process

GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0006091	generation of precursor metabolites and energy
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007584	response to nutrient
GO:0009749	response to glucose
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031018	endocrine pancreas development
GO:0032024	positive regulation of insulin secretion
GO:0038192	gastric inhibitory peptide signaling pathway
GO:0048678	response to axon injury
GO:0051592	response to calcium ion
GO:0070542	response to fatty acid

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030406

View Gene Order

ENSBTAG00000005527

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_18377

Glucagon-type ligand receptors pathway

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.251412 Hs.658534

RefSeq

NM_000164

HUGO

OMIM

CCDS

CCDS12671

HPRD

00670

IMGT

EMBL

GenPept

RNA Seq Atlas