Mus musculus Gene: Mapk8ip3
Summary
InnateDB Gene IDBG-149884.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Mapk8ip3
Gene Name mitogen-activated protein kinase 8 interacting protein 3
Synonyms BB120594; D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2;
Species Mus musculus
Ensembl Gene ENSMUSG00000024163
Encoded Proteins
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase 8 interacting protein 3
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138834:
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:24892153-24936977
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000088345 ENSMUSP00000085683
ENSMUST00000115229 ENSMUSP00000110884
ENSMUST00000115228 ENSMUSP00000110883
ENSMUST00000121787 ENSMUSP00000113753
ENSMUST00000117509 ENSMUSP00000112712
ENSMUST00000121723 ENSMUSP00000113698
ENSMUST00000119115 ENSMUSP00000112955
ENSMUST00000120035 ENSMUSP00000114084
ENSMUST00000146923 ENSMUSP00000114802
ENSMUST00000147109
ENSMUST00000156663
ENSMUST00000125648
ENSMUST00000145357
ENSMUST00000133198
ENSMUST00000132258
ENSMUST00000152486
ENSMUST00000144336
ENSMUST00000146706 ENSMUSP00000118422
ENSMUST00000126280
ENSMUST00000148360
ENSMUST00000178969 ENSMUSP00000136924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005078 MAP-kinase scaffold activity
GO:0005515 protein binding
GO:0008432 JUN kinase binding
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0007411 axon guidance
GO:0007585 respiratory gaseous exchange
GO:0008104 protein localization
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0016192 vesicle-mediated transport
GO:0030900 forebrain development
GO:0043507 positive regulation of JUN kinase activity
GO:0046328 regulation of JNK cascade
GO:0048286 lung alveolus development
GO:0060425 lung morphogenesis
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005790 smooth endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030673 axolemma
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by focal adhesion kinase
Arf6 trafficking events
Cross-References
SwissProt Q9ESN9
TrEMBL D3YWH6 E9Q6B6 E9Q6E0 J3QNR6 Q3UHB5 Q3UYC3 Q8CAB6 Q8CGU7 Q8CHB5
UniProt Splice Variant
Entrez Gene 30957
UniGene Mm.408569 Mm.43081 Mm.483450 Mm.484541 Mm.488379
RefSeq NM_001163447 NM_001163448 NM_001163449 NM_001163450 NM_001163451 NM_001163453 NM_013931
OMIM
CCDS CCDS37498 CCDS50024 CCDS50025 CCDS50026 CCDS50027 CCDS50028 CCDS50029
HPRD
IMGT
MGI ID 1353598 MGI:1353598
MGI Symbol Mapk8ip3
EMBL AB005662 AB043123 AB043124 AB043125 AB043129 AB093282 AC166102 AF178636 AF178637 AF262046 AK039130 AK134797 AK147477 AY099110 BC004003 BC060603 CH466606
GenPept AAF26842 AAF26843 AAG36931 AAH04003 AAH60603 AAM45138 BAA85874 BAB16674 BAB16675 BAB16676 BAB16685 BAC30247 BAC41466 BAE22289 BAE27942 EDL22384
ImmGen Mapk8ip3 (murine)
RNA Seq Atlas 30957