InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mapk8ip3

Summary

InnateDB Gene

IDBG-149884.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mapk8ip3

Gene Name

mitogen-activated protein kinase 8 interacting protein 3

Synonyms

BB120594; D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024163

Encoded Proteins

IDBP-149886

mitogen-activated protein kinase 8 interacting protein 3

IDBP-250049

mitogen-activated protein kinase 8 interacting protein 3

IDBP-250051

mitogen-activated protein kinase 8 interacting protein 3

IDBP-401506

mitogen-activated protein kinase 8 interacting protein 3

IDBP-401504

mitogen-activated protein kinase 8 interacting protein 3

IDBP-401502

mitogen-activated protein kinase 8 interacting protein 3

IDBP-401501

mitogen-activated protein kinase 8 interacting protein 3

IDBP-401500

mitogen-activated protein kinase 8 interacting protein 3

IDBP-535704

mitogen-activated protein kinase 8 interacting protein 3

IDBP-535460

mitogen-activated protein kinase 8 interacting protein 3

IDBP-714661

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138834:
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:24892153-24936977

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000088345	ENSMUSP00000085683
ENSMUST00000115229	ENSMUSP00000110884
ENSMUST00000115228	ENSMUSP00000110883
ENSMUST00000121787	ENSMUSP00000113753
ENSMUST00000117509	ENSMUSP00000112712
ENSMUST00000121723	ENSMUSP00000113698
ENSMUST00000119115	ENSMUSP00000112955
ENSMUST00000120035	ENSMUSP00000114084
ENSMUST00000146923	ENSMUSP00000114802
ENSMUST00000147109
ENSMUST00000156663
ENSMUST00000125648
ENSMUST00000145357
ENSMUST00000133198
ENSMUST00000132258
ENSMUST00000152486
ENSMUST00000144336
ENSMUST00000146706	ENSMUSP00000118422
ENSMUST00000126280
ENSMUST00000148360
ENSMUST00000178969	ENSMUSP00000136924

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005078	MAP-kinase scaffold activity
GO:0005515	protein binding
GO:0008432	JUN kinase binding
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0007411	axon guidance
GO:0007585	respiratory gaseous exchange
GO:0008104	protein localization
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0016192	vesicle-mediated transport
GO:0030900	forebrain development
GO:0031175	neuron projection development
GO:0043507	positive regulation of JUN kinase activity
GO:0045666	positive regulation of neuron differentiation
GO:0046328	regulation of JNK cascade
GO:0048286	lung alveolus development
GO:0060425	lung morphogenesis

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005790	smooth endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030425	dendrite
GO:0030426	growth cone
GO:0030673	axolemma
GO:0043005	neuron projection

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000138834

View Gene Order

ENSBTAG00000002211

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

fak_pathway

Signaling events mediated by focal adhesion kinase

arf6_traffickingpathway

Arf6 trafficking events

Cross-References

SwissProt

Q9ESN9

TrEMBL

Q3UYC3 Q8CAB6 Q8CGU7

UniProt Splice Variant

Entrez Gene

30957

UniGene

Mm.408569 Mm.43081 Mm.483450 Mm.484541 Mm.488379

RefSeq

NM_001163448 NM_001163447 NM_001163449 NM_001163450 NM_001163451 NM_001163453 NM_013931

OMIM

CCDS

CCDS50025 CCDS37498 CCDS50024 CCDS50026 CCDS50027 CCDS50028 CCDS50029

HPRD

IMGT

MGI ID

MGI:1353598

MGI Symbol

Mapk8ip3

EMBL

AB005662 AB043123 AB043124 AB043125 AB043129 AF178636 AF178637 AF262046 AK039130 AK134797 AY099110 BC004003 BC060603

GenPept

AAF26842 AAF26843 AAG36931 AAH04003 AAH60603 AAM45138 BAA85874 BAB16674 BAB16675 BAB16676 BAB16685 BAC30247 BAE22289

RNA Seq Atlas

30957