Mus musculus Gene: Mapk8ip3

Summary
InnateDB Gene IDBG-149884.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Mapk8ip3
Gene Name mitogen-activated protein kinase 8 interacting protein 3
Synonyms BB120594; D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2
Species Mus musculus
Ensembl Gene ENSMUSG00000024163
Encoded Proteins
IDBP-149886 mitogen-activated protein kinase 8 interacting protein 3
IDBP-250049 mitogen-activated protein kinase 8 interacting protein 3
IDBP-250051 mitogen-activated protein kinase 8 interacting protein 3
IDBP-401506 mitogen-activated protein kinase 8 interacting protein 3
IDBP-401504 mitogen-activated protein kinase 8 interacting protein 3
IDBP-401502 mitogen-activated protein kinase 8 interacting protein 3
IDBP-401501 mitogen-activated protein kinase 8 interacting protein 3
IDBP-401500 mitogen-activated protein kinase 8 interacting protein 3
IDBP-535704 mitogen-activated protein kinase 8 interacting protein 3
IDBP-535460 mitogen-activated protein kinase 8 interacting protein 3
IDBP-714661
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138834:
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 24892153-24936977
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000088345  ENSMUSP00000085683
ENSMUST00000115229  ENSMUSP00000110884
ENSMUST00000115228  ENSMUSP00000110883
ENSMUST00000121787  ENSMUSP00000113753
ENSMUST00000117509  ENSMUSP00000112712
ENSMUST00000121723  ENSMUSP00000113698
ENSMUST00000119115  ENSMUSP00000112955
ENSMUST00000120035  ENSMUSP00000114084
ENSMUST00000146923  ENSMUSP00000114802
ENSMUST00000147109 
ENSMUST00000156663 
ENSMUST00000125648 
ENSMUST00000145357 
ENSMUST00000133198 
ENSMUST00000132258 
ENSMUST00000152486 
ENSMUST00000144336 
ENSMUST00000146706  ENSMUSP00000118422
ENSMUST00000126280 
ENSMUST00000148360 
ENSMUST00000178969  ENSMUSP00000136924
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein‑Protein  17
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 23 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005078 MAP-kinase scaffold activity
GO:0005515 protein binding
GO:0008432 JUN kinase binding
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0007411 axon guidance
GO:0007585 respiratory gaseous exchange
GO:0008104 protein localization
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0016192 vesicle-mediated transport
GO:0030900 forebrain development
GO:0043507 positive regulation of JUN kinase activity
GO:0046328 regulation of JNK cascade
GO:0048286 lung alveolus development
GO:0060425 lung morphogenesis
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005790 smooth endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030673 axolemma
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000138834 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000002211 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
mmu04010  MAPK signaling pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010  MAPK signaling pathway
INOH
PID BIOCARTA
PID NCI
arf6_traffickingpathway Arf6 trafficking events
fak_pathway Signaling events mediated by focal adhesion kinase
Cross-References
SwissProt Q9ESN9 
TrEMBL D3YWH6 E9Q6B6 E9Q6E0 J3QNR6 Q3UHB5 Q3UYC3 Q8CAB6 Q8CGU7 Q8CHB5
UniProt Splice Variant
Entrez Gene 30957 
UniGene Mm.408569 Mm.43081 Mm.483450 Mm.484541 Mm.488379
RefSeq NM_001163447  NM_001163448  NM_001163449  NM_001163450  NM_001163451  NM_001163453  NM_013931 
OMIM
CCDS CCDS37498  CCDS50024  CCDS50025  CCDS50026  CCDS50027  CCDS50028  CCDS50029 
HPRD
IMGT
MGI ID MGI:1353598 
MGI Symbol Mapk8ip3
EMBL AB005662 AB043123 AB043124 AB043125 AB043129 AB093282 AC166102 AF178636 AF178637 AF262046 AK039130 AK134797 AK147477 AY099110 BC004003 BC060603 CH466606
GenPept AAF26842  AAF26843  AAG36931  AAH04003  AAH60603  AAM45138  BAA85874  BAB16674  BAB16675  BAB16676  BAB16685  BAC30247  BAC41466  BAE22289  BAE27942  EDL22384 
ImmGen Mapk8ip3 (murine) 
RNA Seq Atlas 30957